PubMed COVID-19 Clinical Care

Effect of the decreased frequency of going out on the association between anxiety and sleep disorder during the COVID-19 pandemic: a mediation analysis

Sunday, July 23, 2023 - 4:00 AM

CONCLUSION: The present study found that anxiety about the COVID-19 pandemic was significantly associated with sleep disorder, with the decreased frequency of going out mediating this association.

A proposed methodology for conducting a remote rigid gas permeable contact lens consultation

Sunday, July 23, 2023 - 4:00 AM

CONCLUSION: This study has developed the components of a remote CL consultation to enable patients who cannot attend scheduled appointments to receive care and advice to ensure the safety of their RGP CL wear. The tools involved in this study are low

Prokaryotic expression of porcine deltacoronavirus S gene truncated segment and establishment of indirect ELISA detection method

Sunday, July 23, 2023 - 4:00 AM

Porcine deltacoronavirus (PDCoV) is an emerging discovered coronavirus that causes significant losses in the global swine industry. This study aimed to establish an indirect ELISA method for detecting PDCoV antibodies using the truncated gene of

Exploring diverse reactive warheads for the design of SARS-CoV-2 main protease inhibitors

Sunday, July 23, 2023 - 4:00 AM

SARS-CoV-2 main protease (M^(pro)) is a validated antiviral drug target of nirmatrelvir, the active ingredient in Pfizer's oral drug Paxlovid. Drug-drug interactions limit the use of Paxlovid. In addition, drug-resistant M^(pro) mutants against

Assessing the Impact of the Zero Mother Mortality Preeclampsia Program on Maternal Mortality Rates at a Single Center in Bandung, West Java (2015-2022): A Retrospective Study

Sunday, July 23, 2023 - 4:00 AM

BACKGROUND The Zero Mother Mortality Preeclampsia (ZOOM) program was adopted as an accelerated initiative to curb mortality related to hypertensive disorders in pregnancy, including preeclampsia. This single-center, retrospective study in Bandung

Correction: Apremilast Adherence and Persistence in Patients with Psoriasis and Psoriatic Arthritis in the Telehealth Setting Versus the In-person Setting During the COVID-19 Pandemic

Sunday, July 23, 2023 - 4:00 AM

No abstract

Poly(vinyl pyrrolidone) derivatives as PEG alternatives for stealth, non-toxic and less immunogenic siRNA-containing lipoplex delivery

Sunday, July 23, 2023 - 4:00 AM

The recent approval of Onpattro® and COVID-19 vaccines has highlighted the value of lipid nanoparticles (LNPs) for the delivery of genetic material. If it is known that PEGylation is crucial to confer stealth properties to LNPs, it is also known that

Mental health and self-rated health of older carers during the COVID-19 pandemic: evidence from England

Sunday, July 23, 2023 - 4:00 AM

CONCLUSION: The health of older carers worsened disproportionately in the first year of the pandemic, a period also characterised by disruptions to support and closure of respite services. Support for carers' mental and physical health requires

Prognostic significance of time trends in treatment of head and neck squamous cell carcinoma

Sunday, July 23, 2023 - 4:00 AM

CONCLUSIONS: Our analysis determined several demographic, referral, and treatment factors impacted TTI. However, increased TTI did not impact survival. Characteristics consistent with advanced disease worsened OS. Despite the pandemic burden

Identification of active compounds of traditional chinese medicine derived from maxing shigan decoction for COVID-19 treatment: a meta-analysis and in silico study

Sunday, July 23, 2023 - 4:00 AM

CONCLUSION: This study demonstrates the important role of MXSGD-related TCM in the treatment of COVID-19.