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PubMed COVID-19 Clinical Care

59031 - 59040 of 63288 results found

Rapid resistance profiling of SARS-CoV-2 protease inhibitors

Date
Thursday, March 30, 2023 - 4:00 AM
Description
Resistance to nirmatrelvir (Paxlovid) has been shown by multiple groups and may already exist in clinical SARS-CoV-2 isolates. Here a panel of SARS-CoV-2 main protease (Mpro) variants and a robust cell-based assay are used to compare the resistance